Basic Course in Pediatric Heart Failure and Heart Transplantation → Principle Challenge in immunosuppressive therapies - Niakoro

Basic Course in Pediatric Heart Failure and Heart Transplantation

Basic Course in Pediatric Heart Failure and Heart Transplantation

Course Content

Total learning: 67 lessons / 6 quizzes Time: 8 hours

Principle Challenge in immunosuppressive therapies

  • The principles are the same for all type of organ transplant; maximize graft protection and minimize side effect.
  • The agents used to prevent rejection act predominantly on T cells.
  • The need for immunosuppression is highest in the first 3 month but  indefinite treatment is needed
  • It increase the risk of infection and malignancy
  • Successful therapy in the post-transplant setting requires maintaining a balance in the degree of immunosuppression (IS)
  • Too little IS can lead to transplant rejection, while too much can lead to opportunistic infections, including viral reactivation and neoplasia (Clinical Microbiology Newsletter. 2016;38:129-134)

  • Principal goal of immunosuppressive therapy in cardiac transplantation: To maintain a quiescent state so as to minimize the risk of allograft rejection or graft dysfunction by achieving adequate immunosuppression, yet also ensuring that this level of immunosuppression does not contribute to long term morbidity (Patel J et al. Transplant Immunology 2008;20:48–54)

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